SPP 1172:  The significance of neuroglia for the formation, function and plasticity of synapses (2004 – 2010)

• The programme is focussed on the following topics:
• neuron-glia interactions at neuronal synapses
• molecular relationships between synaptic elements, extracellular matrix molecules and glial cell processes
• role of glia for the formation, stabilisation and removal of synapses
• modulation of synaptic transmission by glia
• metabolic nuturing of synapses by glia
• significance of glial precursor cells (stem cells) for the formation and function of synapses

• 1^st Meeting of the DFG-Priortity Programme 1172 “The role of neuroglia for the formation, function and plasticity of synapses”, Kaiserslautern (October  14 - 16, 2004)
• 2^nd Meeting of the DFG-Priortity Programme 1172 “The role of neuroglia for the formation, function and plasticity of synapses”, Kaiserslautern (September 22 - 24, 2005)
• 3^rd Meeting of the DFG-Priortity Programme 1172 “The role of neuroglia for the formation, function and plasticity of synapses”, Bonn (September 28 - 30, 2006)
• 4^th Meeting of the DFG-Priortity Programme 1172 “The role of neuroglia for the formation, function and plasticity of synapses”, Bad Dürkheim/Pfalz (October 14 - 16, 2007)
• 5^th Meeting of the DFG-Priortity Programme 1172 “The role of neuroglia for the formation, function and plasticity of synapses”, Berlin (September 18 - 20, 2008)
• 6^th Meeting of the DFG-Priortity Programme 1172 “The role of neuroglia for the formation, function and plasticity of synapses”, Frankfurt/M. (October 2 - 3, 2009)
• Final Meeting of the DFG-Priortity Programme 1172 “The role of neuroglia for the formation, function and plasticity of synapses”, Kaiserslautern (August 26 - 29, 2010)

• Grant application (short version in German language) 2002
• Final report 2010
• Special issue "Synaptic processes - the role of glial cells"

• Analysis of single signalling molecules at the synaptic astroglia-neuron interface (project leader Kirchhoff, Frank)
• Astrocyte-to-neuron communication: functional relevance for synaptic transmission in the respiratory network? (project leader Hülsmann, Swen)
• Communication between cortical neurons and astrocytes by extracellular ATP and glutamate (project leader Illes, Peter)
• Die Rolle astroglialer Subtypen bei der Synapsenbildung adult (re)generierter Neurone (project leader Berninger, Benedikt)
• Glia-mediated control of extracellular GABA/glutamate balance in the developing cortex (project leader Kirischuk, Sergei)
• Glial responses at neuronal synapses and their purinergic modulation (project leader Deitmer, Joachim W.)
• Influence of the constitutive, conditional and inducible astroglia-derived tenascin-C ablation on synaptic function (project leader Schachner, Melitta)
• Investigating the function of astrocytes during neurotrophin-induced synaptogenesis and synaptic plasticity (project leader Dieterich, Daniela C.)
• Investigations on the ephrinA/EphA signalling system at the neuroglial interface - focus on synaptic morphology, plasticity and glutamate signalling (project leader Klein, Rüdiger)
• Coordination project (project leader Deitmer, Joachim W.)
• Modulation of signal transmission in the hippocampus by GluR-type astroglial cells (project leader Seifert, Gerald)
• Modulation of synaptic transmission by a novel activity-dependent regulatory mechanism of astrocytic gap junction coupling (project leader Hülsmann, Swen)
• Neue transgene Mausmodelle zur Untersuchungder Rolle von Astrozyten bei der Synaptogenese in vivo (project leader Pfrieger, Frank W.)
• Neuron-glia interaction at a giant mammalian synapse, the Calyx of Held (project leader Kettenmann, Helmut)
• Regulation of Glycine Neurotransmission by the Glial Glycine Transporter 1. (project leader Eulenburg, Volker)
• Regulation of synapse formation, plasticity and function by astroglial-derived extracellular matrix - tenascin-C and interacting proteoglycan ligands (project leader Faissner, Andreas)
• Role of Müller Glial Cells in Synaptic Development and Functioning of the Mammalian Retina (project leader Reichenbach, Andreas)
• Role of the Perisynaptic Extracellular Matrix in Synaptic Plasticity (project leader Gundelfinger, Eckart D.)
• Synaptically-induced sodium transients in glial cells (project leader Rose, Christine R.)
• Targeting astroglial metabolism in vivo: Consequences for astrocytes, neurons and synapses (project leader Hirrlinger, Ph.D., Johannes)
• The role of cells expressing the proteoglycan NG2 in glial-neuronal signalling and synapse formation (project leader Trotter, Ph.D., Jacqueline)
• Translation control of glial key players in neuron-glia interactions (project leader Theis, Martin)